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. 2017 Nov 13;20(1):17–29. doi: 10.1093/biostatistics/kxx059

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — Probability of recommending a dose above the MTD for the proposed method, referred to as TITE-CRMMC, 24 patients. L stands for likelihood estimation using staged approach. B stands for Bayesian. Grade 2+ indicates the probability of grade 2 or higher toxicity. DLT indicates the probability of DLT. The true MTD based on each constraint is specified in bold. N/A indicates not applicable since the true MTD is the highest dose level.