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WT1-dependent DNMT3A expression in human embryonic kidney (HEK293) isogenic cell lines. (A) Immunoblotting demonstrating elevated DNMT3A protein in WT1 over-expressing cell lines (W210, W203) and EW41 (EGR1 plus WT1 over-expression), relative to IP100 and E6 (EGR1 over-expression). (B) Immunoblotting showing decreased DNMT3A in W210 cells after WT1 knockdown. (C) Decreased DNA methyltransferase enzymatic activity accompanying WT1 knockdown (P < 0.05).
