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DNMT3A and WT1 are co-expressed in the developing kidney and in Wilms' tumour. Immunohistochemical analysis of fetal kidney (FK) and Wilms' tumour (WT) demonstrating nuclear co-expression of WT1 and DNMT3A in blastemal cells (bl). In fetal kidney, overlapping staining is also seen the glomerular primitive Bowman capsule (ca) and the primitive podocytes of the glomerulus (po). Stromal (st) and epithelial (ep) compartments show little or no nuclear staining for WT1 and DNMT3A.
