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. 2018 Dec 10;12:479. doi: 10.3389/fncel.2018.00479

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Copyright © 2018 Sancandi, Schul, Economides, Constanti and Mercer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protocol for dual neurotoxin administration in rats to generate a pre-motor PD model. Behavioral testing (sucrose preference test, rotarod, novel object recognition, hidden food test, habituation/dishabituation test) was carried out before, after toxins and after the 7-day treatment with exendin-4 (EX-4). The study included five experimental groups: sham, sham + EX-4, 6-OHDA + DSP-4 (model), 6-OHDA + DSP-4 + EX-4 (model + EX-4) and 6-OHDA + DSP-4 + EX-4 + EX9-39 (model + EX-4 + EX9-39). Histological procedures occurred after animals were culled at days 23–24.