Table 2.
Cellular densities of diverse interneuronal populations in the PC of the sham animals, sham animals treated with EX-4, pre-motor PD model and model treated with EX-4.
| SHAM + saline | SHAM + EX-4 | 6-OHDA + DSP-4 + saline | 6-OHDA + DSP-4 + EX-4 | |
|---|---|---|---|---|
| GAD-67 | 2587.8 (2247.6–2927.9) |
2808.9 (2067.5–3550.3) |
2610.7 (1908.9–3312.5) |
2178.0 (1742.1–2613.9) |
| PV | 1294.6 (576.5–2012.7) |
950.23 (514.2–1386.2) |
278.7 ∗∗∗∗ (136.6–420.8) |
749.1 #### (581.7–916.6) |
| CB | 843.7 (591.3–1096.1) |
1048.2 (668.2–1428.2) |
110.6 ∗∗∗∗ (26.1–195.1) |
834.2 #### (403.6–1264.8) |
| CR | 736.6 (487.1–986.0) |
727.3 (309.0–1145.6) |
171.8 ∗∗∗∗ (80.2–263.3) |
772.2 #### (473.8–1070.6) |
| CCK | 172.2 (113.8–230.7) |
195.7 (150.2–241.1) |
139.7 (92.8–186.5) | 164.8 (116.4–213.3) |
| SOM | 619.7 (549.5–689.9) |
414.4 (328.3–500.5) |
439.8 (347.6–531.9) |
436.0 (361.2–510.8) |
| NPY | 173.7 (135.9–211.4) |
202.2 (162.6.94–241.9) |
167.6 (120.1–215.1) |
145.8 (104.0–187.6) |
| VIP | 472.8 (329.9–615.7) |
424.9 (348.9–500.8) |
224.5 ∗∗∗ (94.3–354.6) |
482.6 ## (295.5–669.6) |
Data are represented as the median and interquartile range of the number cells per mm3 that are immunopositive for the indicated marker (n = 4–5 animals/per experimental group). GAD-67, glutamic acid decarboxylase-67; PV, parvalbumin; CB, calbindin; CR, calretinin; CCK, cholecystokinin; SOM, somatostatin; NPY, neuropeptide Y; VIP, vasoactive intestinal peptide (Kruskal–Wallis test was used, post hoc analysis for comparisons with Sham animals ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ∗∗∗∗P < 0.0001; post hoc analysis model compared with model treated with EX-4 #P < 0.05; ##P < 0.01; ###P < 0.001; ####P < 0.0001).