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. 2018 Dec 10;12:94. doi: 10.3389/fninf.2018.00094

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Copyright © 2018 Marcoux, Burgos, Bertrand, Teichmann, Routier, Wen, Samper-González, Bottani, Durrleman, Habert, Colliot and for the Alzheimer's Disease Neuroimaging Initiative.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of the pipeline execution. The subject's T1-w MRI is coregistered with the PET image and the PET image is intensity normalized using the average uptake in a reference region. In parallel, cortical surfaces and a parcellation are generated from the subject's T1-w MRI. The PET image, after partial volume correction performed using the parcellation, is robustly projected onto the cortical surface. Finally, regional mean uptake values are extracted from the projected PET data, and the projected PET signal in the subject's native space is spatially normalized to the standard space of FsAverage.