Table 3.
Hematological, Biochemical and Nutritional Parameters in Subjects with Thalassemia by Gender
| Serum Values | Total | % Abnormala | Male | Female |
|---|---|---|---|---|
| No. of Subjects | 41 | 20 | 21 | |
| Hemoglobin (g/dL),c | 10.9 ± 1.5 | 76% | 11.0±1.9 | 10.9±l.l |
| Hematocrit (%) | 32.1 ± 4.3 | 68% | 32.3±5.1 | 32.0±3.3 |
| Albumin (g/dL) | 4.5 ± 0.90 | 3% | 4.5±0.49 | 4.6±1.2 |
| Glucose (mg/dL) | 111.1±54.6 | 35%d | 119.1±66.7 | 103.5±40.3 |
| Alkaline Phosphatase (IU/Le) | 120 ± 57 | 0% | 121.3±58.3 | 120.3 |
| Alanine Transferase (IU/L) | 49.6 ± 39.2 | 33% | 48.5±41.0 | 50.8±38.3 |
| Seram ferritinf (ng/mLg) | 1942 ± 1983 | 100% | 2080±2075 | 1916±2510 |
| Zinc (μg/dL) | 76.1 ± 16.2 | 41% | 77.6±17.8 | 74.3±14.4 |
| Copper (μg/dL)b | 92.7 ± 31.0 | 21% | 78.2±24.0 | 108.1±30.6 |
| Ceruloplasmin (mg/dL) | 24.0 ±6.18 | 6% | 20.0±2.8 | 27.7±6.2 |
| Selenium (μm/L) | 127 ± 29 | 0% | 124.2±23.2 | 130.6±34.3 |
| Vitamin D (ng/mL) | 36.1 ± 14.2 | 35% | 34.3±14.3 | 38.0±14.1 |
| Vitamin C (mg/dL) | 0.93 ± 0.56 | 19% | 0.88±0.43 | 0.99±0.68 |
| α Tocopherol (mg/L) | 8.7 ± 3.3 | 0% | 8.2±3.4 | 9.2±3.1 |
| γ Tocopherol (mg/L) | 2.3 ± 1.2 | 97% | 2.3±1.1 | 2.3±1.4 |
Using reference guidelines published by the Institutes of Medicine (IOM).
Gender differences in circulating copper were determined to be significant (p<0.02). Significance was determined using chi-squared with Fisher’s exact test.
Values are presented as Mean ± SD=standard deviation.
Percent of subjects with a glucose that is elevated, as defined by glucose>100mg/dL fasting. Of note, 5 enrolled subjects were diagnosed with diabetes prior to study entry.
IU=International Unit, as determined by the World Health Organization for an individual nutrient.
Serum Ferritin is the average of all ferritin values drawn within the six months prior to completion of the Block Food Frequency.
To convert ng/mL ferritin to pmol/L, multiply ng/mL by 2.247. To convert pmol/L ferritin to ng/mL, multiply pmol/L by 0.445. Ferritin of 1,000 ng/mL=2247 pmol/L.