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. Author manuscript; available in PMC: 2019 Jul 26.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Jul 4;57(31):9901–9905. doi: 10.1002/anie.201803872

Figure 5.

Figure 5.

Three-component reactions: benzyne + electron-rich alkyne + BCB “dienophile”. Five equivalents of each (relative to the HDDA substrate) were used in each experiment. DMAD = Dimethyl acetylenedicarboxylate.