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Molecular components of the uniporter complex. Data strongly suggest that MCU is the pore. Most but not all experimental evidence suggests that MICU1 and MICU2 are located within the inner mitochondrial space. EMRE appears to link MCU with MICU1 and to be necessary for MCU to open and allow calcium entry (red circles) into the mitochondrial matrix. Not pictured here is MCUb, the dominant negative form of MCU that exists in various ratios with MCU. See text for further details.
