Table 1. Baseline characteristics, cardiac arrest characteristics, and clinical characteristics on ICU admission.
| Variables | All patients (N = 81) | NMB (n = 38) | Placebo (n = 43) | p Value |
|---|---|---|---|---|
| Demographics | ||||
| Male sex, n (%) | 59 (72.8) | 29 (76.3) | 30 (69.8) | 0.508 |
| Age, yr | 62.0 (49.5–70.5) | 65.5 (49.8–76.0) | 61.0 (48.0–66.0) | 0.074 |
| Medical history | ||||
| Congestive heart failure, n (%) | 2 (2.5) | 1 (2.6) | 1(2.3) | 1.000 |
| Ischemic heart disease, n (%) | 5 (6.2) | 4 (10.5) | 1 (2.3) | 0.181 |
| Hypertension, n (%) | 35 (43.2) | 18 (47.4) | 17 (39.5) | 0.508 |
| Diabetes, n (%) | 23 (28.4) | 12 (31.6) | 11 (25.6) | 0.550 |
| Asthma or COPD, n (%) | 8 (9.9) | 6 (15.8) | 2 (4.7) | 0.138 |
| Nephropathy, n (%) | 9 (11.1) | 3 (7.9) | 6 (14.0) | 0.490 |
| Cerebrovascular attack, n (%) | 7 (8.6) | 4 (10.5) | 3 (7.0) | 0.701 |
| Malignancy, n (%) | 3 (3.7) | 1 (2.6) | 2 (4.7) | 1.000 |
| Previous myocardial infarction, n (%) | 5 (6.2) | 2 (5.3) | 3 (7.0) | 1.000 |
| Smoking, n (%) | 20 (24.7) | 10 (26.3) | 10 (23.3) | 0.750 |
| Cardiac arrest characteristics | ||||
| Witnessed, n (%) | 58 (71.6) | 29 (76.3) | 28 (67.4) | 0.619 |
| Bystander CPR, n (%) | 43 (53.1) | 23 (60.5) | 20 (46.5) | 0.439 |
| Primary shockable rhythm, n (%) | 21 (25.9) | 8 (21.1) | 13 (30.2) | 0.384 |
| Time to ROSC, min, median (IQR) | 26.0 (17.5–40.0) | 26.0 (15.0–40.0) | 33.0 (19.0–42.0) | 0.443 |
| Cardiac etiology, n (%) | 46 (56.8) | 22 (57.9) | 24 (55.8) | 0.690 |
| Clinical characteristic on ICU admission | ||||
| Mean blood pressure, mmHg | 86.8 ± 31.2 | 88.6 ± 30.6 | 85.2 ± 32.1 | 0.632 |
| Glasgow Coma Scale, median (IQR) | 3 (3–3) | 3 (3–3) | 3 (3–3) | 0.594 |
| SOFA | 4 (4–12) | 4 (4–10) | 4 (4–13) | 0.775 |
| Shock, n (%) | 51 (63.0) | 23 (60.5) | 28 (65.1) | 0.669 |
| ST elevation myocardial infarction, n (%) | 9 (11.1) | 4 (10.5) | 5 (11.6) | 1.000 |
| Body temperature, °C | 36.0 (35.9–36.3) | 36.1 (36.0–36.3) | 36.0 (35.9–36.4) | 0.827 |
| Serum lactate, mmol/L | 7.7 (3.6–11.0) | 7.8 (3.8–11.1) | 7.3 (3.6–11.1) | 0.854 |
| Serum glucose, mg/dL | 254 (196–315) | 261 ± 110 | 273 ± 118 | 0.635 |
| pH | 7.10 ± 0.23 | 7.06 (6.92–7.29) | 7.11 (6.92–7.28) | 0.883 |
| PaCO2, mmHg | 45.0 (34.8–66.9) | 46.0 (35.0–68.6) | 45.0 (34.0–65.5) | 0.613 |
| PaO2, mmHg | 98.0 (73.5–177.7) | 114 (73–215) | 91 (73–155) | 0.192 |
NMB, neuromuscular blockade; COPD, chronic obstructive pulmonary disease; CPR, cardiopulmonary resuscitation; ROSC, restoration of spontaneous circulation; ICU, intensive care unit; SOFA, sequential organ failure assessment