Table 4. Correlations of complication and local relapse risk, logistic regression.

	Toxicity risk		Relapse risk
	Coefficienta	p	Coefficienta	p
Regression Model significanceb		<.001		.30
Age	- 0.01 [-0.01; 0.01]	.59	0.40 [-0.32; 1.12]	.27
Sexc	- 2.16 [-4.87; 0.54]	.12	0.20 [-0.37; 0.77]	.49
Tumour size	- 0.01 [-0.01; 0.01]	.02	0.17 [-0.32; 0.80]	.61
Petroclival locationd	7.05 [-0.28; 14.38]	.06	- 0.13 [-0.81; 0.55]	.71
Distant from ICA	0.54 [-2.92; 4.00]	.76	0.65 [-0.12; 1.43]	.10
Open Surgery	2.21 [-0.76; 5.18]	.14	- 0.03 [-0.60; 0.55]	.93
Dura opened	8.54 [5.23; 11.86]	<.001	0.42 [-0.16; 1.00]	.16
Partial Resection	1.30 [-2.70; 5.30]	.52	- 0.09 [-0.67; 0.48]	.75
Proton therapy	8.07 [3.82; 12.32]	<.001	0.58 [-0.20; 1.37]	.14

Relapse includes relapse and death; the correlation was calculated using a binary logistic regression test. Complications induced by surgery or radiotherapy were graded from 0 to 5 using the CTCAE v4 and the highest was noted for each patient, the correlation was calculated using an ordinal logistic regression test. Relapse risk was calculated using a binary logistic regression test. ICA Internal carotid artery, OAT Organs at risk near the Clinical Target Volume in proton therapy.

^a Standardized coefficient and 95% confidence interval.

^b Likelihood Ratio Test.

^c the fact to be a female (compared to male).

^d compared to anterior skull base.