Table 2.
MIC (mg/ml) and MBC (mg/ml) of Stem AgNPs, Amphotericin B and its synergistic effect.
| Alone |
Leaf AgNPs + Amphotericin B (AMP) |
FIC |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC |
MFC |
MIC |
MFC |
MIC |
MFC |
|||||||||
| AgNPs | AMP | AgNPs | AMP | AgNPs | AMP | AgNPs | AMP | AgNPs | AMP | ∑FICI | AgNPs | AMP | ∑FICI | |
| C. albicans | 2.5 | 5 | 10 | >10 | 0.156 | 0.156 | 2.5 | 2.5 | 0.062 | 0.031 | 0.093 | 0.25 | ND | ND |
| C. glabrata | 2.5 | 5 | 10 | >10 | 0.156 | 0.156 | 2.5 | 2.5 | 0.062 | 0.031 | 0.093 | 0.25 | ND | ND |
| C. neoformans | 2.5 | 5 | 10 | >10 | 0.156 | 0.156 | 2.5 | 2.5 | 0.05 | 0.5 | 0.55 | 0.25 | ND | ND |
Values are expressed in µg ml−1; ∑FIC (Fractional Inhibitory Concentration Index) = FICA + FICB; FICA = (MICA combination/MICA alone); FICB = (MICB combination/MICB alone) ≤ 0.5 = synergistic, ≥0.5–0.75 = partial synergy; 0.76–1.0 = additive >1.0–4.0 = indifferent (non interactive), >4.0 = antagonistic; ND = Note determined because of high MIC value >10 µg ml−1.