Table 5. Cross-reactivity profile of anti-CHIKV mAbs against flavivirus-infected cells.
| Immunization strategy |
mAb | Cross reactivity test | |
|---|---|---|---|
| DENV 1–4 | ZIKV (SV0010/15) |
||
| B | 3D11 | - | - |
| 11E11 | - | - | |
| 13H11 | - | - | |
| 15B2 | - | - | |
| 19B8 | - | - | |
| RC5-3 | - | - | |
| C | 24B3 | - | - |
| 26A2 | - | - | |
| 32A3a | - | - | |
| 37C7 | - | - | |
| 41G5 | - | - | |
| Control mAb | 4G2a | + | + |
Alexa Fluor 488 signals of each photo were quantified by NIS-Elements software (Nikon Corporation, Tokyo, Japan). Note; + (positive; mean fluorescence intensity/pixel ≥ 15),—(negative; < 5)
a Positive control for Flaviviruses (DENV and ZIKV)