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. 2018 Dec 12;10:6857–6867. doi: 10.2147/CMAR.S188364

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© 2018 Jiang et al. This work is published and licensed by Dove Medical Press Limited

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HJC0152 inhibits the phosphorylation of STAT3 in GC cells.

Note: (A) Chemical structure of HJC0152. (B) Expression of STAT3 and p-STAT3 (Y705 and S727) in six GC cell lines (AGS, HGC-27, MKN28, MKN45, SGC7901, and BGC-823). Western blots showing the levels of p-STAT3 and downstream targets in AGS (C) and MKN45 (D) cells treated with 20 µM HJC0152 for varying durations (0, 1, 2, and 4 hours) or with different concentrations of HJC0152 (0, 5, 10, and 20 µM) for 4 hours. GAPDH was used as internal control.

Abbreviations: GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GC, gastric cancer; STAT3, signal transducer and activator of transcription 3.