Table 3.
Relationship between the number of examined LNs and cancer-specific survival in univariate and multivariate analysis
| Variable | Number | Univariate analysis
|
Multivariate analysis
|
||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
|
| |||||
| Gender | 0.093 | ||||
| Male | 392 | ||||
| Female | 157 | 0.771 (0.569–1.045) | |||
| Age (years) | <0.001 | 1.807 (1.382–2.363) | <0.001 | ||
| ≤65 | 374 | ||||
| >65 | 175 | 1.828 (1.399–2.387) | |||
| Smoking status | 0.052 | ||||
| Never | 226 | ||||
| Former | 323 | 1.306 (0.996–1.711) | |||
| Tumor size (cm) | 0.289 | ||||
| ≤4 | 426 | ||||
| >4 | 123 | 1.179 (0.869–1.598) | |||
| Tumor location | 0.995 | ||||
| Left | 228 | ||||
| Right | 321 | 0.999 (0.767–1.302) | |||
| Histological type | 0.349 | ||||
| Squamous | 174 | ||||
| Adenocarcinoma | 325 | 1.162 (0.868–1.556) | 0.314 | ||
| Adenosqumaous | 38 | 1.376 (0.808–2.343) | 0.240 | ||
| Others | 12 | 0.480 (0.117–1.962) | 0.307 | ||
| Visceral pleura invasion | 0.584 | ||||
| No | 216 | ||||
| Yes | 333 | 1.078 (0.823–1.412) | |||
| Bronchia invasion | 0.040 | 0.795 (0.570–1.109) | 0.177 | ||
| No | 407 | ||||
| Yes | 142 | 0.712 (0.513–0.987) | |||
| Differentiation | 0.172 | ||||
| Well or moderate | 333 | ||||
| Poor or undifferentiated | 216 | 1.202 (0.923–1.567) | |||
| Adjuvant therapy | 0.076 | ||||
| No | 459 | ||||
| Yes | 90 | 0.704 (0.476–1.040) | |||
| Number of examined LNs | 0.045 | 0.854 (0.747–0.976) | 0.020 | ||
| 1–2 | 28 | ||||
| 3–7 | 109 | 0.761 (0.427–1.356) | 0.354 | ||
| 8–11 | 110 | 0.803 (0.452–1.424) | 0.452 | ||
| ≥12 | 302 | 0.566 (0.330–0.972) | 0.039 | ||
| Number of examined N1 station | 0.691 | ||||
| ≥3 | 38 | ||||
| <3 | 511 | 1.112 (0.658–1.880) | |||
| Number of examined N2 station | 0.775 | ||||
| ≥3 | 374 | ||||
| <3 | 175 | 1.042 (0.786–1.380) | |||
| Total resected station | 0.830 | ||||
| ≥6 | 146 | ||||
| <6 | 403 | 1.033 (0.771–1.384) | |||
Abbreviation: LN, lymph node.