. Author manuscript; available in PMC: 2019 Nov 27.

Published in final edited form as: J Am Coll Cardiol. 2018 Nov 27;72(21):2625–2641. doi: 10.1016/j.jacc.2018.09.042

Table 1.

Strengths and Limitations of Select Diagnostic Techniques for the Evaluation of CMD

	Accuracy	Reproducibility	Diagnostic Threshold	Prognostic Validation	Availability	Cost
*Noninvasive^
PET	++++	++++	CFR < 2	++++	++	$$$
CMR	+++	+++	MPRI < 2	++	++	$$$
Doppler echocardiography	++	+++	CFVR < 2	+++	++++	$
*Invasive^
CFR	++++	++++	< 2.3	+++	++++	$$$$
IMR	++++	+++	> 25 U	++	++	$$$$
WIA	+++	Limited data	−4.8	++	++	$$$$

Assumes exclusion of obstructive coronary artery disease

CFR = coronary flow reserve; CFVR = coronary flow velocity reserve; CMD = coronary microvascular disease; CMR = cardiac magnetic resonance; CT = computed tomography; IMR = index of microvascular resistance; MPRI = myocardial perfusion reserve index; PET = positron emission tomography; WIA = wave intensity analysis