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Parafibromin-deficient (HPT-JT type, CDC73 mutated) parathyroid tumors demonstrate eosinophilic cytoplasm, but these tumor cells usually lack the distinct cytoplasmic granularity of usual oxyphil cells and are notable for their relative nuclear enlargement and perinculear cytoplasmic clearing. Hematoxylin and eosin, original magnification 200x.
