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. Author manuscript; available in PMC: 2019 Dec 17.
Published in final edited form as: Analyst. 2018 Dec 17;144(1):206–211. doi: 10.1039/c8an01157e

Fig. 3.

Fig. 3

Indirect and direct co-cultures in the paper-based format. (a) Schematic of the indirect co-culture setup used in this work. (b) MCF7 (orange) invasion from collagen-containing paper scaffolds after a 48 h exposure to conditioned medium (CM) or a monolayer of 32 000 fibro-blasts (green). All signals were normalized to 1% FBS. (c) Schematic of the direct co-culture setup used in this work. (d) MCF7 invasion from collagen-containing paper scaffolds after a 48 incubation in the presence of a 1:1 or 1:3 ratio with either RMF or RMF-HGF cells. All signals were normalized to their starting fluorescence signal. Each bar represents the average and standard deviation of n = 15 replicates. ** p <0.05, and **** p < 0.0001.