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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Shock. 2019 Jan;51(1):10–22. doi: 10.1097/SHK.0000000000001243

Table 3.

Humane Modeling Endpoints in Sepsis Models (2003–2012*)

Defined criteria for euthanasia given& Analgesics used If analgesics used: frequency of application Full anesthesia throughout the duration of experiment
yes: 33
no: 341


 yes: 30
no: 19
not stated: 329

 1×: 14
2–4×: 4
>5×: 4
continuous i.v.: 4
not stated: 4		 yes: 19
not used/not stated: 355
*

Collated data is obtained from review of the 360 most-cited papers (featuring total of 374 animal experiments) identified with ISI Web of Knowledge database (using the query:”sepsis model”).

&

irrespective of mortality as an endpoint. i.v.: intravenous.