Table 2.
Effects of humidification strategy according to oxygen flow rate (non-inferiority analyses) at H6–H8 and H24 (per protocol analysis)
| Oxygen flows | Results presentation | HO group comfort score | NHO group comfort score | Absolute difference between NHO group mean score and HO group mean score [90% CI] |
Relative difference between NHO group mean score and HO group mean score [90% CI] |
Interpretation |
|---|---|---|---|---|---|---|
| ≤4 L/min H6–H8 |
Mean ± SDa | 26.1 ± 19.4 20% NI margin =+5.2 |
27.9 ± 22.2 | + 1.8 [− 2.0; + 5.5] | + 6.9 [− 7.7; + 21.1] | Non-conclusive |
| Median [IQR] | 21 [10.8; 37.5] | 22 [11; 38.5] | ||||
| >4 L/min H6–H8 |
Mean ± SDa | 29.3 ± 22.1 20% NI margin = + 5.9 |
33.9 ± 24.2 | + 4.6 [− 1.6; + 10.8] | + 15.7 [− 5.5; + 36.9] | Non-conclusive |
| Median [IQR] | 22.5 [17.8; 36.5] | 25 [18.5; 45] | ||||
| ≤4 L/min H24 |
Mean ± SDa | 29.6 ± 19.7 20% NI margin = + 5.9 |
24.8 ± 21.0 | − 4.8 [− 9.1; − 0.5] | − 16.2 [− 30.7; − 1.7] | Non-inferiority |
| Median [IQR] | 25.5 [13.5; 42.8] | 21 [12; 34] | ||||
| >4 L/min H24 |
Mean ± SDa | 23.8 ± 16.6 20% NI margin = + 4.8 |
36.4 ± 19.5 | + 12.6 [+ 4.9; + 20.4] | + 52.9 [+ 20.6; + 85.7] | Non-conclusive |
| Median [IQR] | 21 [12; 34] | 33 [18.5; 43.5] |
HO humidified oxygen, NHO non-humidified oxygen, CI confidence interval
aFor non-inferiority analysis