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. 2018 Dec 11;9:612. doi: 10.3389/fgene.2018.00612

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Copyright © 2018 Sollazzo, Genchi, Paglia, Di Giacomo, Pession, de Biase and Grifoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MYC overexpression downregulates survival and epigenetic markers. (A–A2) Immunostaining for dIAP1 (A1, red) and Pc (A2, cyan) on wing discs from late yw; hh-Gal4, UAS-GFP/UAS-dm larvae. (B) Graph comparing the Mean Fluorescence Intensity Arbitrary Units (MFI-AU) of dIAP and Pc staining measured in the P (green bars) and A (grey bars) compartments, ^∗∗∗p ≤ 0.001. (C–C2) Immunostaining for dIAP1 (C1, red) and Pc (C2, cyan) on wing discs from late yw/yw, UAS-PI3K^CAAX; hh-Gal4, UAS-GFP/+ larvae. (D) Graph comparing the Mean Fluorescence Intensity Arbitrary Units (MFI-AU) of dIAP and Pc staining measured in the P (green bars) and A (grey bars) compartments. Basic genotypes are indicated under the figure panels. P compartments are outlined in A1,A2,C1,C2, and disc axes are indicated in A,C. Magnification is 400×.