Table 2.
Comparisons with different thresholds of stromal tumor-infiltrating lymphocytes
| Threshold (%)a | No. of patients (%) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | Youden’s Indexb |
|---|---|---|---|---|---|---|---|
| 10 | 114 (79.72) | 87.21 | 31.58 | 65.79 | 62.07 | 65.03 | 0.188 |
| 20 | 70 (49.0) | 61.83 | 70.18 | 75.71 | 54.79 | 65.03 | 0.318 |
| 30 | 34 (23.78) | 31.4 | 87.72 | 79.41 | 45.87 | 53.85 | 0.191 |
| 40 | 17 (11.89) | 12.79 | 96.49 | 70.59 | 41.27 | 44.76 | 0.093 |
| 50 | 13 (9.1) | 8.14 | 100.00 | 84.62 | 42.31 | 46.15 | 0.081 |
PPV Positive predictive value, NPV negative predictive value
aThreshold of sTILs used to discriminate pCR
bYouden’s index = sensitivity + specificity − 1