Table 3.
Correlation between stromal tumor-infiltrating lymphocytes and pathological complete response in HER2-positive breast cancers
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | |
| Age (years) | ||||||
| < 50 | 1 | – | – | |||
| ≥ 50 | 1.94 | 0.97–3.86 | 0.160 | |||
| Tumor size (cm) | ||||||
| ≤ 2 | 1 | – | – | |||
| 2–5 | 2.47 | 0.65–9.38 | 0.184 | |||
| > 5 | 1.20 | 0.53–2.72 | 0.656 | |||
| Histological grade | ||||||
| 2 | 1 | – | – | |||
| 3 | 0.88 | 0.45–1.72 | 0.708 | |||
| Ki-67 index (%) | ||||||
| ≤ 10 | 1 | – | – | |||
| 10–30 | 1.22 | 0.29–5.22 | 0.786 | |||
| > 30 | 0.76 | 0.37–1.55 | 0.448 | |||
| Nodal status (sTILs per 10% increment) | ||||||
| Negative | 1 | – | – | 1 | – | – |
| Positive | 6.74 | 2.94–15.44 | < 0.001 | 4.28 | 1.60–11.45 | 0.004 |
| Nodal status (sTILs <20% vs ≥20%) | ||||||
| Negative | 1 | – | – | 1 | – | – |
| Positive | 6.74 | 2.94–15.44 | < 0.001 | 4.61 | 1.73–12.30 | 0.002 |
| Lympho-vascular invasion (sTILs per 10% increment) | ||||||
| Negative | 1 | – | – | 1 | – | – |
| Positive | 32.99 | 9.32–116.79 | < 0.001 | 29.38 | 7.38–116.96 | < 0.001 |
| Lympho-vascular invasion (sTILs < 20 vs. ≥ 20%) | ||||||
| Negative | 1 | – | – | 1 | – | – |
| Positive | 32.99 | 9.32–116.79 | < 0.001 | 26.43 | 6.87–101.66 | < 0.001 |
| sTILs (per 10% increment) | 1.05 | 1.02–1.08 | 0.001 | 1.04 | 1.00–1.07 | 0.034 |
| sTILs (%) | ||||||
| < 20 | 1 | – | – | 1 | – | – |
| ≥ 20 | 0.25 | 0.12–0.52 | < 0.001 | 0.35 | 0.14–0.87 | 0.024 |
OR Odds ratio, CI confidence interval,