Table 4.
Association of stromal tumor-infiltrating lymphocytes with disease-free survival and overall survival in HER2-positive breast cancers
| Variables | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| Disease-free survival | Overall survival | |||||||||||
| Age (years) | ||||||||||||
| < 50 | 1 | – | – | 1 | – | – | ||||||
| ≥ 50 | 0.79 | 0.43–1.47 | 0.459 | 0.95 | 0.38–2.35 | 0.903 | ||||||
| Tumor size (cm) | ||||||||||||
| ≤ 2 | 1 | – | – | 1 | – | – | ||||||
| 2–5 | 0.66 | 0.18–2.36 | 0.521 | 0.28 | 0.04–2.24 | 0.23 | ||||||
| > 5 | 0.91 | 0.45–1.82 | 0.779 | 0.45 | 0.18–1.13 | 0.09 | ||||||
| Histological grade | ||||||||||||
| 2 | 1 | – | – | 1 | – | – | ||||||
| 3 | 0.78 | 0.42–1.47 | 0.446 | 1.43 | 0.58–3.55 | 0.443 | ||||||
| Ki67 index (%) | ||||||||||||
| ≤ 10 | 1 | – | – | 1 | – | – | ||||||
| 10–30 | 1.09 | 0.26–4.65 | 0.906 | 0.78 | 0.22–1.34 | 0.951 | ||||||
| > 30 | 1.26 | 0.67–2.37 | 0.473 | 0.88 | 0.33–2.31 | 0.792 | ||||||
| Lympho-vascular invasion (sTILs per 10% increment) | ||||||||||||
| Negative | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
| Positive | 0.26 | 0.14–0.47 | <0.001 | 1.05 | 0.49–2.29 | 0.895 | 0.11 | 0.04–0.32 | <0.001 | 0.38 | 0.09–1.62 | 0.192 |
| Lympho-vascular invasion (sTILs < 20 vs. ≥ 20%) | ||||||||||||
| Negative | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
| Positive | 0.26 | 0.14–0.47 | <0.001 | 0.89 | 0.42–1.87 | 0.757 | 0.11 | 0.04–0.32 | <0.001 | 0.31 | 0.08–1.16 | 0.102 |
| Nodal status (sTILs per 10% increment) | ||||||||||||
| Negative | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
| Positive | 0.13 | 0.05–0.34 | <0.001 | 0.34 | 0.12–0.99 | 0.048 | 0.17 | 0.01–0.70 | 0.032 | 0.00 | 0.00–9.79E* + 09 | 0.921 |
| Nodal status (sTILs < 20 vs. ≥ 20%) | ||||||||||||
| Negative | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
| Positive | 0.13 | 0.05–0.34 | <0.001 | 0.3 | 0.10–0.84 | 0.022 | 0.17 | 0.01–0.70 | 0.032 | 0.00 | 0.00–9.15E* + 09 | 0.920 |
| pCR (sTILs per 10% increment) | ||||||||||||
| No | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
| Yes | 6.37 | 3.06–13.30 | <0.001 | 2.97 | 1.15–7.66 | 0.024 | 8.85 | 2.58–30.38 | 0.001 | 1.27 | 0.23–7.07 | 0.783 |
| pCR (sTILs < 20 vs. ≥ 20%) | ||||||||||||
| No | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
| Yes | 6.37 | 3.06–13.30 | <0.001 | 2.48 | 0.96–6.41 | 0.046 | 8.85 | 2.58–30.38 | 0.001 | 1.17 | 0.23–6.13 | 0.849 |
| sTILs (per 10% increase) | 0.91 | 0.88–0.95 | < 0.001 | 0.93 | 0.90–0.97 | < 0.001 | 0.88 | 0.83–0.94 | < 0.001 | 0.92 | 0.86–0.98 | 0.009 |
| sTILs | ||||||||||||
| < 20% | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
| ≥ 20% | 6.60 | 2.91–14.95 | <0.001 | 3.87 | 1.65–9.12 | 0.002 | 10.29 | 2.37–44.66 | 0.002 | 4.74 | 1.02–22.01 | 0.047 |
HR Hazard ratio, CI confidence interval
*E Scientific notation