Fig. 4.

Scratch assay performed on confluent MDA-MB231 cells showing (A) light microscopy examination of the effect of PLGA-shRNA-1-NP and PLGA-shRNA-4-NP at 2.0 μg ml⁻¹ on cell migration and (B) graphical representation of the dimensional change over 72 h using PLGA-shRNA-1-NP at three different concentrations and (C) graphical representation of the dimensional change over 72 h using PLGA-shRNA-4-NP at three different concentrations). Data are mean ± SD with n = 6. *P < 0.05, **P < 0.01, ***P < 0.001, C1, C2 and C3 are 0.5 μg ml⁻¹, 1.0 μg ml⁻¹ and 2.0 μg ml⁻¹ of entrapped shRNA-4