Table 2.
Systemic therapy.
| Pt. # | Protocol | Systemic therapy before RT | Systemic therapy with RT | Systemic therapy after RT |
|---|---|---|---|---|
| 1 | SJYC07 [105] | HDC×4 cycles with MTX, VCR, VLB, CYC and CDDP then TPT×2 cycles, followed by CYC maintenance | CDDP with VPA | Metronomic chemotherapy: VP-16, TMZ, VPA, CRA, MET, MLT×6 cycles |
| 2 | Head Start III [106] | CDDP, VP-16, VCR, CYC, and HD MTX followed by a cycle of VP-16, TMZ | None | MC (VPA, MLT, and MET) and VP-16, TMZ, CRA |
| 3 | SJMB 03 [107] | VCR, CDDP, and CYC×2 cycles | None | None |
| 4 | ACNS 0332 [108] | None | VCR and CDDP | HD CDDP, VCR, CYC1 with ASCT. Switched to MC (ISO, MET, MLT, VPA, VP-16, TMZ, CRA, CYC, and celecoxib) |
| 5 | None | IFO, VP-16, and VCR×3 cycles | None | 2× cycles HD CDDP/THIO with ASCT |
| 6 | ACNS 0332 [108] | Vorinostat, CRA | CDDP and VCR | None |
| 7 | CCG-99703 [109] | CDDP, VCR, CYC, VP-16×3 cycles, then CDDP/THIO×3 cycles followed by SCT | None | None |
Pt. # = Patient number, RT = radiotherapy, ASCT = autologous stem cell transplant, 1aborted due to hearing loss with cisplatin, HDC = high dose chemotherapy, MC = metronomic chemotherapy, MTX = methotrexate, VCR = vincristine, VLB = vinblastine, CYC = cyclophosphamide, CDDP = cisplatin, TPT = topotecan, VPA = valproic acid, VP-16 = etoposide, TMZ = temozolomide, CRA = cis-retinoic acid, MET = metformin, MLT = melatonin, ISO = isotretinoin, IFO = ifosfamide, THIO = thiotepa (THIO).