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. 2018 Nov 7;15:31–37. doi: 10.1016/j.ctro.2018.11.002

Table 4.

Treatment and outcomes of long Term Survivors (≥36 months) in literature.

Age (mo) Loc. Treatment XRT details Chemo Outcome OS Ref
15 C S (GTR), C, RT 20 Gy CSI + 26 Gy TBB IT MTX×3 NED 161 [50]
17 RTP S (GTR), C, RT 55 Gy LF VCR, VP-16, CDDP, CYC, CP NED 44 [50]
36 LF S, C, RT Unknown Unknown NED 42 [1], [67]
67.2 LFT S (GTR), C, RT 35.2 Gy CSI, 20 Gy TBB Per HIT91 NED 152.4 [66]
40.8 LP S (GTR), C, RT 35.2 Gy CSI, 20 Gy TBB Per HIT91 NED 112.8 [66]
67.2 RFP S (GTR), C, RT 36 Gy CSI, 30 Gy TBB Per HIT SKK2000 DOD 37.2 [66]
48 RP S (GTR), C, RT 35.8 Gy CSI, 19.9 Gy TBB CP, VCR, CYC, CDDP NED 84 [78]
7 LTP S (GTR), C None VCR, CDDP, VP-16, CYC, MTX NED 48 [55]
23 ST S, C, RT Unknown Unknown Alive 56 [7]
138 ST S (GTR), RT CSI + TBB1 None NED 183.9 [69]
34.8 SC S (GTR), C, RT CSI + TBB1 VPCP×2, HDC NED 43.2 [69]
26.4 ST S (GTR), C, RT CSI + TBB1 VPCP×2, HDC NED 143.6 [69]
38.4 ST S (STR), C, RT CSI + TBB1 VPCP×2, HDC AWSD 90.9 [69]
81.6 ST S (GTR), C, RT CSI + TBB1 VPCP×2, MP + CDDP×2 NED 63.8 [69]
24 ST S (STR), C, RT CSI + TBB1 VPCP×2, MP×2, THIO×2 NED 143.4 [69]
31.2 ITE S (GTR), C, RT CSI + TBB1 VPCP×2, HCD NED 103.3 [69]
139.2 ITE S, C, RT CSI + TBB1 VPCP×2, THIO×2, TMZ×2 NED 70.5 [69]
24 LC, LO S (GTR), C, RT 32 Gy CSI, 24 Gy TBB HRP + IT VCR, CDDP, VP-16 NED 52 [80]

S = surgery, C = chemotherapy, RT = radiotherapy, CSI = craniospinal irradiation, GTR = gross total resection, STR = subtotal resection, TBB = tumor bed boost, LF = local field, NED = no evidence of disease, DOD = died of disease, AWSD = alive with stable disease, IT = intrathecal, R = right, L = left, T = Temporal, P = parietal, F = frontal, C = cerebellum, O = occipital, ST = supratentorial, ITE = infratentorial, SC = spinal cord, MP = melphalan, VP-16 = etoposide, THIO = thiotepa, VPCP = VP-16 + CP, CP = carboplatin, CDDP = cisplatin, VCR = vincristine, CYC = cyclophosphamide, TMZ = temozolomide, HDC = MP + CDDP + THIO, HRP = 2× VCR + CYC + VP-16 → 2× VCR + CP + VP-16 → 2× VCR + CDDP + VP-16 → IT triplet ×7, ? = unspecified, 1 per protocol in Ref. [110].