Table 3.
Multivariate Analyses for TTP and OS According to CHFR and CIMP Status
| TTP |
OS |
||||
|---|---|---|---|---|---|
| Covariates in the Final Model | Adjusted HR (95% CI) | P | Covariates in the Final Model | Adjusted HR (95% CI) | P |
| CHFR/CIMP status | <.001 | CHFR/CIMP status | <.001 | ||
| CHFR unmethylated/CIMP negative | 2.43 (1.23-4.81) | .011 | CHFR unmethylated/CIMP negative | 3.94 (2.02-7.69) | <.001 |
| CHFR unmethylated/CIMP positive | 6.45 (2.66-15.63) | <.001 | CHFR unmethylated/CIMP positive | 4.72 (2.10-10.64) | <.001 |
| No. prior treatment(s) | <.001 | No. prior treatment(s) | .001 | ||
| 1 | 2.77 (1.58-4.84) | <.001 | 1 | 0.98 (0.59-1.63) | .935 |
| ≥2 | 3.84 (1.87-7.88) | <.001 | ≥2 | 3.42 (1.78-6.60) | <.001 |
| CEA >5.0 ng/ml | 2.80 (1.66-4.72) | <.001 | |||
Multivariate analyses were performed by Cox regression analysis with forward conditional selection method adjusted for age (continuous), sex, differentiation (well to moderately differentiated vs. poorly differentiated), tumor location (right vs. left), metastatic organs (1-2 vs. ≥3), CEA level (≤5 vs. >5.0 ng/ml), BRAF mutation, hMLH1/hMSH2, number of prior treatment(s), and CHFR/CIMP status.