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Anticoagulant properties of dalteparin and gsHep. (A) Glycol-split heparin had negligible anti-Factor Xa activity compared to dalteparin at all concentrations tested. (B) Glycol-split heparin had significantly reduced ability to prolong aPTT clotting time compared to dalteparin at concentrations beyond 5 μg/mL. ***P < 0.0001 compared to dalteparin at equivalent concentration. aPTT, activated partial thromboplastin time. n = 3 independent experiments.
