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. 2018 May 30;99(5):1082–1090. doi: 10.1093/biolre/ioy127

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© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Dalteparin and gsHep elicit similar gene expression and protein release from first trimester placental villous explants. (A) Both treatments dose-dependently suppressed mRNA levels of PlGF and sFLT1 while increasing mRNA levels of the proliferation gene PCNA. (B) Glycol-split heparin and dalteparin increased PlGF release into the conditioned media without significantly affecting sFlt1 release. *P < 0.05, **P < 0.01, ***P < 0.001 compared to no heparin controls. n = 6 placenta and media samples. PlGF, placental growth factor; sFlt1, soluble fms-like tyrosine kinase-1; PCNA, proliferating cell nuclear antigen.