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. 2018 Dec 17;9:5342. doi: 10.1038/s41467-018-07718-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Abrogation of BAG3–Hsp70 by pharmaceutical intervention. a, b Immunofluorescence pictures using BAG3 (green) and ubiquitin (FK2; red) antibodies of primary control versus BAG3^P209L patient fibroblasts (a) or primary control versus BAG3^P470S patient fibroblasts (b). Cells were either untreated, treated for 6 h with bortezomib followed by a 20 h recovery or treated for 6 h with bortezomib followed by a 20 h recovery in the presence of 0.05 µM JG98. Arrows indicate BAG3-punctae. Scale bar = 5 μm. Source data are provided as a Source data file