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. 2018 Dec 17;8:17915. doi: 10.1038/s41598-018-36244-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of intestinal microbiota on D-amino acid production. (a) Relative abundances of colonic bacteria in Ex-GF mice by 16S rRNA gene amplicon sequencing. Bacteria with less than 0.1% abundance were included in others. Data of class, order, and family levels are shown in Supplementary Fig. S3. (b) Correlation between relative abundances of bacteria (genus level) and D-amino acid concentrations. Red and blue lines show significant positive and negative correlation, respectively. Unclassified bacteria that showed significant correlation are not shown.