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. 2018 Dec 11;9:596. doi: 10.3389/fgene.2018.00596

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Copyright © 2018 Cosín-Tomás, Álvarez-López, Companys-Alemany, Kaliman, González-Castillo, Ortuño-Sahagún, Pallàs and Griñán-Ferré.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNAs dysregulation in SAMP8 mice compared to SAMR1 mice at 2 and 9 months of age. Representative pie chart of miRNAs altered in the hippocampus of 2-month-old SAMP8 mice compared to age-matched SAMR1 (A). Representative pie chart of miRNAs altered in the hippocampus of 9-month-old SAMP8 mice compared to age-matched SAMR1 (B). Venn diagram highlighting hippocampal miRNAs concurrently altered in SAMP8 mice at 2 and 9 months of age (C). Venn diagram includes miRNAs significantly dysregulated in 2-month-old SAMP8 mice compared to age-matched SAMR1 (left circle), and miRNAs significantly dysregulated in 9-month-old SAMP8 mice compared to age-matched SAMR1 (right circle). The intersection of circles corresponds to miRNAs that are altered in SAMP8 mice at both early adulthood and aged stages.