Table 1. miRNA list involved in lung adenocarcinoma TKI resistance through apoptosis regulation.

miRNA	Expression	Putative targets and mechanisms involved in TKI resistance
miR-21	Up	Targeting PTEN and PDCD4, and inhibiting apoptosis (12)
miR-19b	Up	Enhancing apoptosis resistance by targeting PP2A and BIM (13)
miR-221/222	Up	Targeting multiple genes, such as TRAIL, CDKN1B, PTEN, TIMP3, PUMA, BIM, and APAF1, thus to inhibit apoptosis (14)
miR-200	Down	Targeting MIG6 to induce cell apoptosis (15)
miR-451	Down	Downregulating RAB14 and increasing the expression of BAX or Bad, thus enhancing apoptosis (16)
miR-34a	Down	Targeting MET and inducing apoptosis (17)

TKI, tyrosine kinase inhibitors.