Azathioprine |
2–3 mg/kg/day |
Mycophenolate mofetil |
2–3 gram/day |
Methotrexate |
20–25 mg/week |
Tacrolimus |
4–8 mg/day (depending on plasma trough levels) |
Ciclosporin |
2–5 mg/kg/day |
Sulfasalazine |
2–3 g/day |
Dapsone |
2–3 mg/kg/day |
Thalidomide (exceptional use) |
50–300 mg/day |
Colchicine |
0.5–2 mg/day |
Prednisolone |
Variable dose (depending on indication and stage of treatment) |
Parenteral treatment |
|
Cyclophosphamide |
15 mg/kg (vasculitis regimens) |
Anti-TNF α inhibitors |
|
Infliximab |
5 mg/kg at 0, 2 and 6 weeks then onceevery 8 weeks |
Adalimumab |
40 mg every 2 weeks |
Etanercept |
50 mg/week |
Certolizumab |
400 mg at 0, 2 and 4 weeks then once every 4 weeks |
Rituximab |
1 g at 0 and 2 weeks |
Interferon α |
Various regimens for Roferon A and pegylated interferon α 2b |
Alemtuzumab |
3 mg (day 1), 10 mg (day 3), 30 mg (day 5), 30 mg (day 8), 30 mg (day 10) and 30 mg (day 12) |