FIGURE 4.

Comparative excisional wound healing in control and 5-HTR1A agonist treated group (excisional punch biopsy model). The wound tissue sections were prepared 7-days after wounding and Masson’s trichrome was staining performed. Scale bars represented at 500 μm (A). Wound length (μm) decreased in 5-HTR1A agonist treated mice group (B). Significantly reduced wound area (×10³ μm²) shown in 5-HTR1A agonist treated group (C) (n = 2 wound images per specimen). Wound cellularity significantly decreased in 5-HTR1A agonist treated group (D), image scale bars represented at 50 μm. Comparative wound cellularity was expressed as percentage number of cell count (n = 2 wound images per specimen) (F). Comparative percentage BrdU +ve cells between agonist and control, image scale bars represented at 50 μm (E,G), (n = 4 images per specimen). Results were presented as mean ± 95 CI (confidence interval). Two-way ANOVA was performed and significance levels were set at ^∗P < 0.05, ^∗∗P < 0.01.