Table II.
Gene ontology analysis of differentially expressed genes associated with chronic lymphocytic leukemiaa.
| Category | Term | Count | P-value |
|---|---|---|---|
| Upregulated | |||
| GOTERM_BP_DIRECT | GO:0035556~intracellular signal transduction | 16 | 2.64×10−5 |
| GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway | 7 | 5.49×10−4 | |
| GO:0008283~cell proliferation | 12 | 1.89×10−3 | |
| GO:0030854~positive regulation of granulocyte differentiation | 3 | 2.27×10−3 | |
| GO:1901385~regulation of voltage-gated calcium channel activity | 3 | 2.27×10−3 | |
| GOTERM_MF | GO:0005515~protein binding | 122 | 6.86×10−6 |
| _DIRECT | GO:0019901~protein kinase binding | 14 | 1.72×10−4 |
| GO:0005524~ATP binding | 31 | 4.04×10−4 | |
| GO:0004715~non-membrane spanning protein tyrosine kinase activity | 5 | 1.35×10−3 | |
| GO:0042169~SH2 domain binding | 4 | 3.39×10−3 | |
| GOTERM_CC | GO:0005886~plasma membrane | 65 | 1.81×10−4 |
| _DIRECT | GO:0005829~cytosol | 53 | 7.60×10−4 |
| GO:0009897~external side of plasma membrane | 9 | 1.63×10−3 | |
| GO:0045121~membrane raft | 8 | 5.46×10−3 | |
| GO:0030175~filopodium | 5 | 6.11×10−3 | |
| Downregulated | GO:0006955~immune | 31 | 1.58×10−12 |
| GOTERM_BP | response | ||
| _DIRECT | GO:0050776~regulation of immune response | 21 | 2.84×10−12 |
| GO:0006958~complement activation, classical pathway | 14 | 2.97×10−9 | |
| GO:0006911~phagocytosis, engulfment | 8 | 7.61×10−7 | |
| GO:0050853~B cell receptor signaling pathway | 9 | 1.36×10−6 | |
| GOTERM_MF | GO:0003823~antigen binding | 15 | 3.62×10−10 |
| _DIRECT | GO:0042803~protein homodimerization activity | 29 | 4.07×10−6 |
| GO:0034987~immunoglobulin receptor binding | 5 | 5.43×10−4 | |
| GO:0004872~receptor activity | 11 | 1.51×10−3 | |
| GO:0005515~protein binding | 154 | 2.01×10−3 | |
| GOTERM_CC | GO:0070062~extracellular exosome | 97 | 8.36×10−18 |
| _DIRECT | GO:0005886~plasma membrane | 113 | 1.27×10−13 |
| GO:0009986~cell surface | 24 | 3.43×10−6 | |
| GO:0072562~blood microparticle | 12 | 1.19×10−5 | |
| GO:0005887~integral component of plasma membrane | 37 | 5.02×10−4 |
a
If there were more than five terms in this category, the first five terms were only selected based on the P-value. ‘Count’ corresponds to the number of enriched genes in each term. BP, biological processes; CC, component classification; MF, molecular function.