Table III.
Kyoto Encyclopedia of Genes and Genomes pathway analysis of differentially expressed genes associated with chronic lymphocytic leukemiaa.
| Category | Term | Count | P-value | Genes |
|---|---|---|---|---|
| Upregulated DEGs | hsa04261:Adrenergic signaling in cardiomyocytes | 7 | 9.44×10−3 | ADRB2, ATP2B4, BCL2, PPP2R5C, CREB3L2, CACNB2, RAPGEF3 |
| hsa00561:Glycerolipid metabolism | 4 | 3.52×10−2 | DGKA, LPL, AGPAT5, ALDH3A2 | |
| hsa04024:cAMP signaling pathway | 7 | 3.63×10−2 | ADRB2, ATP2B4, PDE4A, RRAS2, CREB3L2, RAPGEF3, MYL9 | |
| hsa04010:MAPK signaling pathway | 7 | 3.89×10−2 | PTPN7, MAP3K5, RASGRF1, RRAS2, CACNB2, MYC, RASA1, CDC25B | |
| Downregulated DEGs | hsa05144:Malaria | 8 | 3.32×10−5 | KLRB1, GYPC, CR1, KLRC4-KLRK1, ITGB2, HBA1, HBB, TGFB |
| hsa04640:Hematopoietic cell lineage | 9 | 1.90×10−4 | CR1, CR2, CD44, CD1C, CD22, ITGA4, IL7R, ITGAM, CD1D | |
| hsa05202:Transcriptional dysregulation in cancer | 12 | 3.22×10−4 | JUP, CD86, CEBPB, ID2, REL, LMO2, BCL2A1, AFF1, ZBTB16, MYC, ITGAM, KLF3 | |
| hsa05140:Leishmaniasis | 8 | 3.64×10−4 | FOS, CR1, NFKBIA, ITGB2, ITGA4, ITGAM, TGFB1, IFNGR1 | |
| hsa05323:Rheumatoid arthritis | 7 | 6.30×10−3 | FOS, CD86, CCL3, ITGB2, IL15, LTB, TGFB1 |
a
If there were more than five terms in this category, the first five terms were only selected based on the P-value. ‘Count’ corresponds to the number of enriched genes in each term.