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. 2018 Nov 20;19(1):400–406. doi: 10.3892/mmr.2018.9671

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — IL-6 regulates the expression levels of PPAR-γ and visfatin in BeWo cells. BeWo cells were incubated with IL-6 (0–10 ng/ml) for 48 h, and in the presence or absence of IL-6 (5 ng/ml) for 12, 24, 48 and 72 h. (A and B) IL-6 reduced the mRNA levels of PPAR-γ and visfatin. (C and D) Time course experiments indicated the inhibitory effects of IL-6 (5 ng/ml) on visfatin and PPAR-γ mRNA, which peaked at 48 h. (E and F) Expression levels of visfatin were correlated with the expression of PPAR-γ. *P<0.05 vs. CON. CON, control; IL-6, interleukin 6; PPAR-γ, peroxisome proliferator-activated receptor-γ.