Table II.

GO and KEGG pathway analysis of hub genes.

Term	Count	P-value	Genes	Fold enrichment	FDR
GOTERM_BP_DIRECT
GO:0022617-extracellular matrix disassembly	6	1.36×10−8	MMP9, MMP11, FN1, MMP1, LAMC2, SPP1	69.77285319	1.78×10−5
GO:0030198-extracellular matrix organization	7	3.87×10−8	FN1, SERPINE1, LAMC2, SPP1, COL4A1, ITGA6, COL1A1	31.56390977	5.06×10−5
GO:0050900-leukocyte migration	6	1.48×10−7	MMP9, FN1, MMP1, CEACAM1, ITGA6, COL1A1	43.46505608	1.94×10−4
GO:0030574-collagen catabolic process	5	5.64×10−7	MMP9, MMP11, MMP1, COL4A1, COL1A1	69.04605263	7.37×10−4
GO:0007155-cell adhesion	7	5.67×10−6	FN1, LAMC2, CEACAM1, SPP1, FAT1, ITGA6, COL1A1	13.47827084	0.007408
GO:0006508-proteolysis	4	0.015348	MMP9, MMP11, TMPRSS11D, MMP1	7.070315789	18.30441
GO:0030335-positive regulation of cell migration	3	0.016282	LAMC2, ITGA6, COL1A1	14.40961098	19.31187
GO:0001525-angiogenesis	3	0.023357	FN1, SERPINE1, CEACAM1	11.88954449	26.57648
GOTERM_CC_DIRECT
GO:0005576-extracellular region	10	7.46×10−6	MMP9, MMP11, FN1, TMPRSS11D, SERPINE1, MMP1, LAMC2, SPP1, COL4A1, COL1A1	5.957502452	0.007625
GO:0031012-extracellular matrix	6	7.87×10−6	MMP11, FN1, SERPINE1, MMP1, COL4A1, COL1A1	19.44238976	0.008049
GO:0001725-stress fiber	3	0.001279	MYH7, ABLIM1, ACTA1	53.28654971	1.300056
GO:0005615-extracellular space	7	0.001379	MMP9, FN1, SERPINE1, LAMC2, SPP1, COL1A1, ACTA1	4.984487946	1.401185
GO:0005578-proteinaceous extracellular matrix	4	0.002179	MMP9, MMP11, FN1, MMP1	14.31578947	2.205664
GO:0030175-filopodium	3	0.002199	FAT1, ITGA6, ACTA1	40.52779837	2.225839
GO:0070062-extracellular exosome	9	0.003242	MMP9, FN1, TMPRSS11D, SERPINE1, CEACAM1, SPP1, FAT1, GPD1L, ACTA1	3.070943099	3.265211
GO:0030027-lamellipodium	3	0.010687	ABLIM1, FAT1, ACTA1	17.98421053	10.40403
GO:0048471-perinuclear region of cytoplasm	4	0.021939	ATP2A1, LAMC2, SPP1, FAT1	6.178150691	20.29296
GOTERM_MF_DIRECT
GO:0004252-serine-type endopeptidase activity	4	0.00235	MMP9, MMP11, TMPRSS11D, MMP1	13.93684211	2.240613
GO:0004222-metalloendopeptidase activity	3	0.006336	MMP9, MMP11, MMP1	23.58779693	5.938097
GO:0003779-actin binding	3	0.034758	MYH7, ABLIM1, CEACAM1	9.587845513	28.8746
GO:0005509-calcium ion binding	4	0.038688	MMP11, ATP2A1, MMP1, FAT1	4.956617485	31.61489
KEGG_PATHWAY
hsa04512: ECM-receptor interaction	6	2.08×10−7	FN1, LAMC2, SPP1, COL4A1, ITGA6, COL1A1	36.65782493	1.93×10−4
hsa04510: Focal adhesion	6	1.50×10−5	FN1, LAMC2, SPP1, COL4A1, ITGA6, COL1A1	15.48170276	0.013864
hsa04151: PI3K-Akt signaling pathway	6	1.78×10−4	FN1, LAMC2, SPP1, COL4A1, ITGA6, COL1A1	9.244147157	0.165019
hsa05200: Pathways in cancer	6	3.29×10−4	MMP9, FN1, MMP1, LAMC2, COL4A1, ITGA6	8.115091016	0.304375
hsa05222: Small cell lung cancer	4	3.65×10−4	FN1, LAMC2, COL4A1, ITGA6	25.01357466	0.33712
hsa05146: Amoebiasis	4	6.98×10−4	FN1, LAMC2, COL4A1, COL1A1	20.05805515	0.644143

GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes.