Table II.

KEGG analysis of distinct methylated genes in pathways. KEGG analysis of distinct hepermethylated genes and hypomethylated genes in focal adhesion and ECM-receptor interaction pathways.

Pathway ID	Description	P-value	Hypermethylated Genes	Hypomethylated Genes
hsa04510	Focal adhesion	3.38×10−05	COL5A1 LAMB1 ITGA9 PDK1 FYN VWF AKT3 COL1A2 VEGFC MAPK9 ZYX BCAR1 CRK PARVB PIK3R1 PIK3CB THBS2 FN1 ITGAV COL11A2 PRKCA LAMB3 SOS1 CAPN2 LAMA2 DOCK1 RASGRF1 TNR COL6A3 PTK2 MYLK3 COL4A1 ITGB5 COL5A2 FIGF	ITGA8
hsa04512	ECM-receptor interaction	1.18×10−04	COL5A1 LAMB1 SDC2 ITGA9 VWF COL1A2 THBS2 FN1 ITGAV COL11A2 LAMB3 LAMA2 TNR COL6A3 COL4A1 ITGB5 CD44 COL5A2	ITGA8

KEGG, Kyoto encyclopedia of genes and genomes; ECM, extracellular matrix.