Table 1.
Summary for mechanisms of EA for regulating neurotropic and transcriptional factors against ischemic brain injury.
| References | Species/model | Acupuncture type/frequency/intensity/time | Acupoints | Results |
|---|---|---|---|---|
| Wang et al., 2003 | Wistar rat/MCAO | EA/20–3 HZ/3 mA/30 min | Baihui (DU20) Renzhong (DU26) | Enhancement of the VEGF expression |
| Pan et al., 2012 | SD rat/MCAO | EA/20 HZ/2–4 V/30 min | Hegu (LI4) Quchi (LI 11) | Up-regulation of serum VEGF |
| Tao et al., 2016 | SD rat/MCAO | EA/1–20 HZ/30 min | Quchi (LI11) Zusanli(ST36) | Enhancement of BDNF |
| Kim et al., 2013b | C57BL/6J/photothrombotic cortical ischemia model | EA/20 HZ/1 mA/20 min | Baihui (GV20) Dazhui(GV14) | Increase of BDNF and SDF-1α |
| Kim et al., 2012 | SD rat/MCAO | EA/3 HZ/until the limb and the ear twitched/5 min | Baihui (GV20) | Motor recovery improvement and BDNF/trkB promotion |
| Ma and Luo, 2008 | Wistar rat/MCAO | EA/40–60HZ/5 V/15 min | Hegu (LI 4) | Angiogenesis factors promotion and anti-angiogenesis factors down-regulation |
| Zhou et al., 2011 | rat/MCAO | EA/20 min | Zusanli (ST36) Neiguan (PC 6) | Promotion of GAP-43 |
| Huang et al., 2017b | SD rat/MCAO | EA/ 20 Hz/30 min | Zusanli (ST36) Quchi (LI11) | Up-regulation of Gap-43; down-regulation of Nogo-A. |