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. 2018 Dec 11;12:874. doi: 10.3389/fnins.2018.00874

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Copyright © 2018 Kishi and Gotoh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Local changes in 3D genome organization during neural differentiation. (A) Intra-TAD interactions between binding regions for cell type-specific transcription factors such as Pax6, NeuroD2, and Tbr1. (B) Polycomb (PRC2)-mediated interactions between promoters and poised enhancers lead to the activation of anterior neural genes during differentiation. (C) In cortical neurons, H3K9me3 deposition catalyzed by Setdb1 prevents aberrant CTCF binding at Pcdh gene clusters. Knockout (KO) of Setdb1 induces excessive insulation and upregulation of Pcdh gene expression.