Table II.
Genotype distribution in groups of recurrence of cholangitis, preoperative jaundice, types of gallstone or recurrence of PIS.
| Recurrence of cholangitis | Preoperative jaundice | Types of gallstone | Recurrence of PIS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mutation (n) | Yes 309 (%) | No 134 (%) | P-value | Yes 143 (%) | No 300 (%) | P-value | CBS 420 (%) | CS 23 (%) | P-value | Yes 95 (%) | No 348 (%) | P-value |
| RS3815675T >C | ||||||||||||
| TT (n=218) | 154 (49.8) | 64 (47.8) | 0.222 | 71 (49.7) | 147 (49.0) | 0.895 | 209 (49.8) | 9 (39.1) | 0.426 | 46 (48.4) | 172 (49.4) | 0.266 |
| TC (n=179) | 128 (41.4) | 51 (38.1) | 56 (39.2) | 123 (41.0) | 169 (40.2) | 10 (43.5) | 43 (45.3) | 136 (39.1) | ||||
| CC (n=46) | 27 (8.7) | 19 (14.2) | 16 (11.1) | 30 (10.0) | 42 (10.0) | 4 (17.4) | 6 (6.3) | 40 (11.5) | ||||
| RS2287616T >C | ||||||||||||
| TT (n=210) | 148 (47.9) | 62 (46.3) | 0.143 | 68 (47.6) | 142 (47.3) | 0.998 | 201 (47.9) | 9 (39.1) | 0.493 | 48 (50.5) | 162 (46.6) | 0.303 |
| TC (n=186) | 134 (43.4) | 52 (38.8) | 60 (42.0) | 126 (42.0) | 176 (41.9) | 10 (43.5) | 41 (43.2) | 145 (41.7) | ||||
| CC (n=47) | 27 (8.7) | 20 (14.9) | 15 (10.5) | 32 (10.7) | 43 (10.2) | 4 (17.4) | 6 (6.3) | 41 (11.8) | ||||
| RS2287617G >A | ||||||||||||
| GG (n=440) | 308 (99.7) | 132 (98.5) | 0.168 | 141 (98.6) | 299 (99.7) | 0.510 | 418 (99.5) | 22 (95.7) | 0.369 | 92 (96.8) | 348 (100) | 0.009 |
| GA (n=3) | 1 (0.3) | 2 (1.5) | 2 (1.4) | 1 (0.3) | 2 (0.5) | 1 (4.3) | 3 (3.2) | 0 (0.0) | ||||
| AA (n=0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
| RS2287622T >C | ||||||||||||
| TT (n=39) | 25 (8.1) | 14 (10.4) | 0.621 | 15 (10.5) | 24 (8.0) | 0.679 | 38 (9.0) | 1 (4.4) | 0.693 | 12 (12.6) | 27 (7.8) | 0.061 |
| TC (n=187) | 134 (43.4) | 53 (39.6) | 60 (42.0) | 127 (42.3) | 176 (41.9) | 11 (47.8) | 46 (48.4) | 141 (40.5) | ||||
| CC (n=217) | 150 (48.5) | 67 (50.0) | 68 (47.6) | 149 (49.7) | 206 (49.0) | 11 (47.8) | 37 (38.9) | 180 (51.7) | ||||
| RS118109635C>T | ||||||||||||
| CC (n=423) | 295 (95.5) | 128 (95.5) | 0.980 | 132 (92.3) | 291 (97.0) | 0.026 | 402 (95.7) | 21 (91.3) | 0.634 | 90 (95.5) | 333 (95.7) | 0.692 |
| CT (n=20) | 14 (4.5) | 6 (4.5) | 11 (7.7) | 9 (3.0) | 18 (4.3) | 2 (8.7) | 5 (5.3) | 15 (4.3) | ||||
| TT (n=0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
| RS497692A >G | ||||||||||||
| AA (n=55) | 37 (12.0) | 18 (13.4) | 0.828 | 13 (9.1) | 42 (14.0) | 0.011 | 51 (12.1) | 4 (17.4) | 0.599 | 13 (13.7) | 42 (12.1) | 0.560 |
| AG (n=194) | 138 (44.7) | 56 (41.8) | 53 (37.1) | 141 (47.0) | 183 (43.6) | 11 (47.8) | 45 (47.4) | 149 (42.8) | ||||
| GG (n=194) | 134 (43.4) | 60 (44.8) | 77 (53.8) | 117 (39.0) | 186 (44.3) | 8 (34.8) | 37 (38.9) | 157 (45.1) | ||||
CBS, bilirubinate stones; CS, cholesterol stones; PIS, primary intrahepatic stones.