Table 4.

Risk of bias of the included in vivo studies.

Study	A	B	C	D	E	F	G	H	I	J	Total
Jiang et al., 1982	√		√			√					3
Tang et al., 1989	√	√				√					3
Li et al., 1996	√	√				√					3
Zhang et al., 2010	√	√	√			√				√	5
Lu et al., 2010	√		√			√					3
Li et al., 2012	√	√	√			√			√	√	6
Yin et al., 2013	√	√	√			√			√	√	6
Yu J. et al., 2015	√	√	√			√			√	√	6
Wei et al., 2016	√	√	√			√					4
Song et al., 2016	√	√	√			√			√	√	6
Fan et al., 2016	√	√	√			√			√	√	6
Li et al., 2016	√	√	√			√			√	√	6
Hu et al., 2016	√	√	√			√			√	√	6
Yin et al., 2017	√	√	√	√		√			√	√	7
Gao et al., 2017	√	√	√			√			√	√	6
Dong et al., 2009	√	√	√			√				√	5
Xiang et al., 2009	√	√	√			√					4
Cheng et al., 2010	√	√	√			√					4
Zhao et al., 2012	√	√	√			√					4
Quan et al., 2012	√	√	√			√					4
Cui G. et al., 2013	√	√	√			√			√	√	6
Chen et al., 2014	√	√	√			√					4
Cui et al., 2014	√	√	√			√				√	5
Wang et al., 2016	√	√				√			√	√	5
Zhang X. et al., 2017	√		√			√				√	4
Wang et al., 2017	√	√	√			√			√	√	6
Tang et al., 2018	√	√				√			√	√	5

Studies fulfilling the criteria of: A, peer reviewed publication; B, control of temperature; C, random allocation to treatment or control; D, blinded induction of model; E, blinded assessment of outcome; F, use of anesthetic without significant intrinsic vascular protection activity; G, appropriate animal model (aged, diabetic, or hypertensive); H, sample size calculation; I, compliance with animal welfare regulations; J, statement of potential conflict of interests.