Table 2.
Myofilament model parameter values
| Myofilament Parameter | Normal | cAF | Effect of cAF Remodeling on APD-ANM |
|---|---|---|---|
| kon | 47.5 1/µMs | Normal × 100% to normal × 300% (25% increments) | Increases |
| kn_p* | 152.5 s−1 | Normal × 100% to normal × 300% (25% increments) | None |
| gapp* | 186 s−1 | Normal × 100% to normal × 300% (25% increments) | None |
| hb | 34 s−1 | Normal × 100% to normal × 300% (25% increments) | None |
| perm50 | 0.5 (unitless) | Normal × 100% to normal × 20% (10% increments) | Increases |
| koffL | 250 s−1 | Normal × 100% to normal × 20% (10% increments) | None |
| koffH | 25 s−1 | Normal × 100% to normal × 20% (10% increments) | Increases |
| kp_n* | 24 s−1 | Normal × 100% to normal × 20% (10% increments) | None |
| fapp | 4,800 s−1 | Normal × 100% to normal × 20% (10% increments) | None |
| hf | 10 s−1 | Normal × 100% to normal × 20% (10% increments) | None |
| gxb | 30 s−1 | Normal × 100% to normal × 20% (10% increments) | None |
cAF, chronic atrial fibrillation; APD-ANM, action potential duration alternans-normalized magnitude. Normal and cAF values of myofilament model parameters in the human left and right atrial myocyte models are shown. Myofilament parameters in parmin are indicated by an asterisk in the Myofilament Parameter column. The effect of cAF remodeling on APD-ANM column presents the effects of cAF remodeling on the normalized magnitude of APD-alterans (APD-ANM).