Table 2.
Endothelial function in patients with cystic fibrosis before and after acute sildenafil and placebo
| Sildenafil |
Placebo |
||||
|---|---|---|---|---|---|
| Variable | Pre | Post | Pre | Post | P Value |
| Diameter, mm | |||||
| Baseline | 3.05 (0.61) | 3.05 (0.58) | 3.04 (0.67) | 3.00 (0.64) | 0.350 |
| Peak | 3.29 (0.62) | 3.24 (0.58) | 3.26 (0.65) | 3.19 (0.65) | 0.110 |
| Absolute change | 0.23 (0.12) | 0.24 (0.13) | 0.23 (0.11) | 0.22 (0.11) | 0.848 |
| FMD, % | 7.8 (4.3) | 7.3 (4.8) | 7.7 (4.3) | 6.6 (3.7) | 0.776 |
| Shear, s−1, AUC | 49,384 (23,214) | 43,899 (27,793) | 50,265 (23,373) | 42,328 (17,335) | 0.760 |
| FMD (%)/shear (s−1, AUC) | 0.17 (0.07) | 0.17 (0.08) | 0.16 (0.05) | 0.16 (0.08) | 0.867 |
| Time to peak, s | 46 (20) | 45 (24) | 43 (15) | 41 (21) | 0.862 |
Values are means (SD). FMD, flow-mediated dilation; AUC, area under the curve.