Fig. 3.
Drastic reduction in single channel gating probability in the presence of Nav1.5-L325R channels. A: representative traces of single channel recordings in human embryonic kidney-293 cells expressing wild-type (WT) or WT + L325R mutant channels. B: number of events as a function of time. C: open probability for WT or WT + L325R channels. D: sum of 500 single channel recordings at −20 mV. E: representative traces at −20 mV in the whole cell configuration for cells expressing Nav1.5-WT or Nav1.5-WT + L325R channels. INa, inward Na+ current.