Fig. 1.

Circulating insulin-like growth factor (IGF-1) and testosterone levels. A and B: circulating IGF-1 levels (A) and testosterone levels (B) (log transformed) in ~135 days of gestation (dGA) fetal sheep after maternal exposure to vehicle or to testosterone propionate from 30 to 59 dGA (early T) or from 60 to 90 dGA (late T). Values are means ± SE. Control: n = 8 (A) or 6 (B) female fetuses and n = 4 male fetuses; early T: n = 4 female fetuses and n = 4 (A) or 3 (B) male fetuses; and late T: n = 5 female fetuses and n = 5 male fetuses. Comparisons were performed by two-way ANOVA. *Different from control and late T; †different from female fetuses (P < 0.05, exact values in text).