Fig. 2.

Sex × myocardial infarction (MI) and ovariectomy (OVX) × MI interactions for the percent immobility in the forced swim test. Values are means ± SE; n = 8–11 rats/group. One-way ANOVA was done to compare all OVX groups with the sham OVX-sham MI group, and two-way ANOVA was done for sex × MI and OVX × MI interactions followed by a Bonferroni post hoc test. A: effects of sex and MI. MI effect: F = 4.7, P = 0.039; sex effect: F = 26.7, P < 0.0001. B: effects of OVX and MI. MI × OVX interaction: F = 4.4, P = 0.04. OVX effect: F = 50.5, P < 0.0001. *P < 0.05 vs. the male sham group; ‡P < 0.0001 vs. male groups; ^aP < 0.05 vs. the sham OVX-sham MI group; ^bP < 0.05 vs. the OVX-sham MI group; ^dP < 0.05 vs. OVX-17β-estradiol (E₂) groups.